What to Use Now that NIA24 is Discontinued?

I’ll admit it: I have a lot of friends and close contacts who are, well, skincare fanatics. And why not? With more brands and products out there than ever before at every price, it’s no wonder that we’re all a little skincare-crazed.

That said, a topic that has been coming up in conversation recently is that StriVectin discontinued the NIA24 line on December 1, 2019. According to PimaDerm, StriVectin made the difficult business decision to focus on their StriVectin retail brand only and end all investment into a medical grade brand.

And, at first glance, this is a real shame for NIA24 lovers. For those of you who weren’t familiar with the brand, NIA24 was the only skincare brand to use vitamin B3 in the form of Pro-Niacin™, or myristyl nicotinate, an ester derived from reacting myristic acid and nicotinic acid (University of Kentucky). In Experimental Dermatology, it was mentioned that myristyl nicotinate increased skin thickness, increased rates of skin renewal, and decreased skin’s water loss. In the study, myristyl nicotinate was found to work by delivering NAD and increasing nicotinic acid within the skin.

Why is Nicotinic Acid Preferred Over Niacinamide (by Some)?: Three Major Reasons

In fact, providing increased barrier function is the major benefit of using nicotinate versus its more popular derivative, niacinamide. When formulating with vitamin B3, most skincare manufacturers choose to use niacinamide instead of nicotinate, because the latter can be associated with skin redness and irritation. However, given by the amount of people who are upset NIA24 was discontinued, the fact that the water-retaining skin benefits of nicotinate are now gone is a bit devastating.

Another benefit to using NIA24’s myristyl nicotinate versus niacinamide is simply the acidic pH of myristyl nicotinate. Myristyl nicotinate was developed to deliver nicotinic acid into the skin, with a pH desired under 5.0. On the other hand, niacinamide has a pH of 5.0-7.0 (TheSkinCareEdit). This means that myristyl nicotinate has the added benefit of acting as an acid, such as skin exfoliation, skin sloughing, and, ultimately, skin smoothing.

The final benefit of myristyl nicotinate over other forms of niacin/vitamin B3 is that other forms have not been proven as effective in combating sun damage because it cannot be effectively delivered to the skin cells for conversion to the active form, NAD, and it does not stimulate the release of leptin. Unlike nicotinamide, the myristyl nicotinate molecule consists of nicotinic acid and a lipophilic tail which enables it to be absorbed through the lipid-rich stratum corneum and to penetrate the other layers of the epidermis. In turn, leptin is a natural repair hormone that produces a signal within skin cells through a signaling cascade that affects metabolism, wound healing, and growth and development of skin cells. Its mechanisms of action are quite complex and only having been discovered in 1994, are not fully known. Leptin has been shown to enhance wound healing through its role as a mediator of keratinocyte (skin cell) proliferation and re-epithelialization (Skin Etc).

What Should NIA24 Users Choose Instead?

The most obvious choice is to move from StriVectin-owned NIA24 products to StriVectin products that contain myristyl nicotinate.

Below, I listed the NIA24 products, with the StriVectin product with myristyl nicotinate I would recommend using instead:

StriVectin Hyaluronic Gel Cushion Cleanser

Instead of NIA24 Gentle Cleansing Cream, try StriVectin Hyaluronic Gel Cushion Cleanser.

StriVectin Glycolic Skin Reset Mask

Instead of NIA24 Physical Cleansing Scrub… well, honestly, there is no direct equivalent. For whatever reason, StriVectin has stayed away from physical exfoliation (i.e., scrubs, microdermabrasion treatments, etc.) with products containing myristyl nicotinate. At any rate, if you want a good chemical exfoliation treatment, you could try StriVectin Glycolic Skin Reset Mask as a 10-minute leave-on and rinse-off treatment after cleansing. I recommend using one to three times a week, depending on your skin.

StriVectin Oleic Rapid Recovery Milk

Instead of NIA24 Rapid Redness Recovery, choose StriVectin Oleic Rapid Recovery Milk.

StriVectin Advanced Retinol Intensive Night Moisturizer

Instead of NIA24 Fully Charged Serum + Moisturizer, which featured myristyl nicotinate, panthenol (vitamin B5), plant-based antioxidants, and a low concentration of glycolic acid, your closest StriVectin equivalent is to switch to StriVectin Advanced Retinol Intensive Night Moisturizer, which contains myristyl nicotinate, plant-based antioxidants, and a mild form of retinol, retinyl palmitate. I wish there was a direct AHA serum/moisturizer equivalent to the NIA24 product, but to the best of my knowledge, there isn’t one.

StriVectin Full Screen Broad Spectrum SPF 30 Clear Finish

Instead of NIA24 Sun Damage Prevention UVA/UVB Sunscreen SPF 30 PA+++, try StriVectin Full Screen Broad Spectrum SPF 30 Clear Finish. Both are chemical sunscreens with myristyl nicotinate.

StriVectin Crepe Control Tightening Body Cream

Instead of NIA24 Age Recovery For Decolletage And Hands, try StriVectin Crepe Control Tightening Body Cream.

In Summary

Some people prefer myristyl nicotinate over niacinamide because:

  • Myristyl nicotinate is associated with decreased skin water loss and skin thickness. Niacinamide is not.
  • Myristyl nicotinate is more acidic than niacinamide when delivered into the skin, and hence may have more skin-smoothing and exfoliating properties.
  • Lastly, myristyl nicotinate is converted into the skin into NAD and triggers leptin, whereas niacinamide does not. This results in what some believe to be more effective sun damage correction and skin-soothing properties.

On the other hand, niacinamide has been associated with less irritation and redness of the skin, which is why many companies prefer to formulate with it.

And, if you’re looking for alternatives to your favorite NIA24 products, I recommend the following:

And, if all else fails, I know that Exclusive Beauty Club is still selling NIA24 products, until they run out. Products generally have a shelf life of about two years, so if you want to buy and stock up, that’s an option to get you through the next few years as well!

25 Comments. Leave new

  • What is an alternative for NIA 24 Intensive recovery complex face cream?

    Reply
    • K. Hendricks
      April 8, 2022 4:50 pm

      What is a replacement for NIA24 Intensive Recovery Complex face cream? I am so disappointed it was discontinued. Thank you.

      Reply
      • I was using this product for years and am about to run out also looking for something comparable.

        Reply
  • Lora Baumann
    July 1, 2021 4:19 pm

    Hi I ordered through Amazon Prime 6 tubes of the NIA 24 spf 30
    Sun damage prevention because my dermatologist ran out. I’ve been using it for years as my everyday sunscreen- moisturizer.
    I’m trying to get a call back from the beauty club to find out why the date on the crimp and the part no are different looking as the tubes o have at home. I’m concerned this is a knock off. I bought 6 and all expire on AU 22
    And that’s how the tube crimp lists expiration date. They do not take your call they tell you to leave a message they do not return emails they do not return phone calls I’m honestly worried that this is a knock off and I should return all six tubes to Amazon they do list on their website and Amazon‘s website that they expire August 1922 but why is it all the other products they list do not have expiration dates? Are you sure I can trust this club and this product in particular? Thank you!

    Reply
  • karen carsello
    August 11, 2021 5:37 am

    I am so devastated to learn too late that my Nia24 Skin Strengthen Complex is discontinued. I always bought a few at a time and by the time I ran out of my tubes it had been gone a full year :(. Any recommendations for Skin Strengthening Complex replacemenr? That formula was magic for my skin.

    Reply
    • Hi Karen, I agree with you that cream was like mgic dor sure! No one seems to answer my question either. They say the Strivectin products are similar and better but I tried them and I don’t find that to be true. So my search continues. I don’t see anything out there even remotely close to it.

      Reply
    • Hi Karen, I agree with you that cream was like mgic dor sure! No one seems to answer my question either. They say the Strivectin products are similar and better but I tried them and I don’t find that to be true. So my search continues. I don’t see anything out there even remotely close to it.

      Reply
    • Hi Karen, I agree with you that cream was like mgic dor sure! No one seems to answer my question either. They say the Strivectin products are similar and better but I tried them and I don’t find that to be true. So my search continues. I don’t see anything out there even remotely close to it.

      Reply
    • Hi Karen, I agree with you that cream was like mgic dor sure! No one seems to answer my question either. They say the Strivectin products are similar and better but I tried them and I don’t find that to be true. So my search continues. I don’t see anything out there even remotely close to it.

      Reply
    • Hi Karen, I agree with you that cream was like mgic dor sure! No one seems to answer my question either. They say the Strivectin products are similar and better but I tried them and I don’t find that to be true. So my search continues. I don’t see anything out there even remotely close to it.

      Reply
  • Paula DeFreitas
    November 22, 2021 8:37 pm

    You didn’t mention Skin Strengthening Complex-Nia 24?? Any thoughts on this product?
    Thanks Paula

    Reply
    • Hi Karen, I agree with you that cream was like mgic dor sure! No one seems to answer my question either. They say the Strivectin products are similar and better but I tried them and I don’t find that to be true. So my search continues. I don’t see anything out there even remotely close to it.

      Reply
  • Nicole Shirley
    January 18, 2022 1:18 pm

    Totally desperate! Your recommendation for UVA/ UVB is sold out too!

    Reply
  • I would like to know your suggestion for replacing Nia Skin Strenthening Complex product. This has been sold out on Amazon. I have used this for years.

    Reply
  • I also would like to know your suggestion for replacing Nia 24 Skin Strengthening complex please.

    Reply
  • What can be used in place of Mia 24 intensive recovery complex?

    Reply
  • What is alternative to NIA intensive recovery complex I have been using this for years and love it !

    Reply
  • Shirley Jones
    March 5, 2022 4:47 pm

    Replacement for nia24 skin strengthening complex

    Reply
  • I would also like a suggestion for replacing skin strengthening complex! I have used it for years and it dramatically improved my skin, now I am running out of my last few tubes I stocked up on (that may not even be good any more) because I have no idea what a suitable replacement would be… Desperate here, please help all of us seeking an alternative to this amazing product. I am extremely unhappy with Strivectin

    Reply
  • Sabine T Smith
    March 10, 2022 10:29 pm

    HELLO??? Anybody home? Great article but….please respond to those of us who need a substitute for the skin strengthening complex!

    Reply
  • Sorry for the delay. The best substitute I know of for the NIA24 Strengthening Complex is actually Paula’s Choice 20% Niacinamide Serum. It, like the NIA24 product, has enough vitamin B3 to turn your face red (if it’s strong enough to take it to begin with)! Quick results and ultra concentrated like the NIA24 Strengthening Complex. https://www.paulaschoice.com/clinical-niacinamide-20pct-treatment/803-8030.html?p=SKINYOURWAY&utm_source=google&utm_medium=cpc&utm_campaign=PLA%7CUS%7CNB%7CFull&utm_term=&utm_content=&p=SKINYOURWAY&gclid=EAIaIQobChMIr7-dsc689gIVpIlbCh3W5QlgEAQYCiABEgIUhfD_BwE

    Reply
  • I also would like to know your suggestion for replacing Nia 24 Skin Strengthening complex please. Is the ONLY cream that my skin will tolerate and look beautiful

    Reply
  • Actually I need the replacement for Nia 24 intense recovery complex please

    Reply
  • I am also searching for a replacement for the NIA 24 Intensive Recovery Complex . I have used the product for years and sorry to see it is no longer available.
    Amy

    Reply

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